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ey0017.11-10 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.10. The [beta]3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

BS Finlin , H Memetimin , B Zhu , AL Confides , HJ Vekaria , RH El Khouli , ZR Johnson , PM Westgate , J Chen , AJ Morris , PG Sullivan , EE Dupont-Versteegden , PA Kern

To read the full abstract: J Clin Invest. 2020;130(5):23192331.This clinical study assessed the effect of the β3-adrenergic agonist mirabegron on glucose homeostasis in obese individuals.Chronic activation of β3-receptors in mice leads to the appearance of brown-like (e.g. beige) adipocytes in white adipose tissue, a process referred to as ...

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ey0016.14-11 | (1) | ESPEYB16

14.11. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

M Fulde , F Sommer , B Chassaing , K van Vorst , A Dupont , M Hensel , M Basic , R Klopfleisch , P Rosenstiel , A Bleich , F Backhed , AT Gewirtz , MW Hornef

To read the full abstract: Nature 2018;560:489493.This paper reports competitive gut colonization experiments in mice. Compared to adult mice, neonatal mice showed much higher expression of the flagellin receptor Tlr5 in their intestinal epithelial cells, and exposure to this protein during the first 2 weeks of life, before weaning, was crucial in determining lifelong...

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ESPE Yearbook of Paediatric Endocrinology

11.10. The [beta]3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans

14.11. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

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